BIG MEDICINE follows the personal stories of severely obese patients who turn to Houston’s Methodist Weight Management Center as a life-changing last resort. One of the most innovative bariatric surgery practices, Methodist adheres to a long-term, multidisciplinary approach that includes a plan for lifelong follow-up. At the heart of the operation is passionate father and son surgeon team Robert and Garth Davis, a pair who have dedicated their professional lives to raising awareness about obesity. 

BIG MEDICINE offers a behind-the-scenes look into the controversial world of bariatric surgery. The series chronicles the emotional journeys and transformation of obese people who have opted to undergo weight-loss surgery in an attempt to regain their lives. Patients are captured at various stages in the process – before and during the surgery, through recovery and post-op care and often through cosmetic procedures designed to remove sagging skin after dramatic weight loss.

Often as gripping as the patient stories is the colorful relationship between this father and son team where old school meets new school head on. Dr. Robert Davis, aka "big D," is true to the old ways of medicine and sometimes finds new techniques too flashy or unnecessary, while Dr. Garth Davis, aka "little D," is eager to modernize the business. Despite these differences, the pair unites in the operating room to fight a common enemy and change lives forever.